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'CAR pooling' screens identify most effective cancer immunotherapy cells

Medical Xpress

In recent years, genetically re-engineered immune cells—armed with molecular weaponry to recognize and destroy tumor cells—have changed the landscape of cancer treatment.

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Novel genomic screening tool enables precision reverse-engineering of genetic programming in cells

Medical Xpress

Collaborative research led by investigators at Dana-Farber/Boston Children's Cancer and Blood Disorders Center defines a novel approach to understanding how certain proteins called transcription factors determine which genetic programs will drive cell growth and maturation. The study is published in the journal Science.

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Portable Assay Offers Rapid, Low-Cost TB Diagnoses

Physician's Weekly

Researchers have engineered a portable “lab‑in‑tube” (LIT) assay that detects Mycobacterium tuberculosis (Mtb) DNA directly from blood, saliva, or sputum in less than 60 minutes at a relatively low cost, according to a study published in Science Translational Medicine.

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Reducing The Effort for Performing Systematic Reviews Using Natural Language Processing And Large Language Models [Systematic review, meta-analysis, or scoping review]

Annals of Family Medicine

Objective The aim is to evaluate the feasibility of an instructed large language model (LLM) to assist with human synthesis such as temporal topic search and screening by citation in systematic reviews for Brain-Heart-Interconnectome (BHI) to support reporting guidelines, such as CONSORT and SPIRIT.

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The Future Of Vision And Eye Care

The Medical Futurist

The 80-year-old Ray Flynn lost his central vision entirely, but with the help of the retinal implant, he could make out shapes on the computer screen. Running trials in animals will take additional engineering and safety tests. However, things are moving fast, and success doesn’t come easy for the pioneers of any medical field.

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New Report: U.S. Primary Care System Crumbling Amid Historic Disinvestment and Surge in Chronic Diseases

The Physicians Foundation

“Health systems and payers are asking primary care physicians to take on more — manage multiple complex conditions, answer patient emails, handle insurance administration, and provide mental health and social needs screenings,” said Christopher F. Koller, President of the Milbank Memorial Fund.

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How Your Emotional Health Impacts Blood Pressure

Imperial Center Family Medicine

It’s similar to revving a car engine for too long while staying still. However, chronic stress keeps your body in a continuous state of high alert. Over time, this can cause persistent hypertension and extra strain on your cardiac system.