April, 2024

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Key Facts GPs Should Know About GLP-1 Analogs

Family Medicine Initiative

Demand for new obesity medications like semaglutide (GLP-1 analogs) is high, but availability is low. So, which patients should get them first? What are the true benefits and side effects? Patients ask me these questions fairly often, so I know it’s important for GPs to know the key facts. I therefore reviewed the main research studies and guidelines and tried to summarize them briefly and clearly in this article. 1.

Diabetes 130
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Omega Institute – Powered by Me Retreat

Intuitive Intelligence

Are you ready for a vacation? Imagine a retreat that propels you towards personal growth and deeper understanding. This June 9th-14th, join me at Omega Institute in Rhinebeck, New York, for a week-long adventure framed around the experiences of my book Powered by Me: From Burned Out to Fully Charged at Work and in Life. I had the pleasure to sit down with my assistant, Phoebe Shaw to reflect on everything that Powered by Me is.

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Recognizing Red Flags for Cancer: The Importance of Early Detection

Myriad Genetics

Cancer often begins with subtle warning signs that are easily overlooked. Early detection is key to successful treatment and improved outcomes. Among the various types of cancer, breast cancer is one of the most prevalent in women worldwide. 1 Understanding the red flags for cancer, the subtle signs and symptoms that warrant attention and potential screening, particularly for breast cancer, can empower individuals to take proactive steps towards their health.

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How to Prevent a Potentially Fatal Aortic Dissection

Vascular Physician

How to Prevent a Potentially Fatal Aortic Dissection High blood pressure is a well-known medical condition that many people understand is a risk factor for heart attacks, strokes, and diabetes. Unfortunately, high blood pressure is also a risk for lesser known but no less serious conditions. High blood pressure is the most common cause of aortic dissections, a condition whose symptoms can be mistaken for a stroke or heart attack and are often fatal.

ER 52
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Reflections On Healthcare Access

University of Utah Family Medicine Residency

by Hendrik Stegall, MD Utahns can’t find a doctor. That was the highlight of a recent Salt Lake Tribune article, which suggested that many parts of Utah have fewer than one MD per 1,000 residents.

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Dr. Marsh Shares 3 Tips for Healthy Feet

Logansport Memorial Hospital

The average person takes about 3,500 steps a day, or roughly 1.5 miles. Each step can place 2-3 times the force of your body weight on your feet. Most of us rely on our feet and ankles to take us from Point A to Point B without any problems. However, some of us are on our feet all day! It’s important to maintain the health of your feet because they can be a clue to your overall health.

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Episode 331: Neurology VMR – Headaches and loss of sensation in the left leg

The Clinical Problem Solvers

[link] Episode 331: Neurology VMR – Headaches and loss of sensation in the left leg We continue our campaign to #EndNeurophobia, with the help of Dr. Aaron Berkowitz. This time, Hans presents a case of headaches and loss of sensation in the left leg to Andrew and Maria. Neurology DDx Schema Hans Kaus Hans Kaus received his MD from Ross University School of Medicine.

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AMPLIFY™ Technology Enhances Prenatal Screening for 22q11.2 Microdeletion

Myriad Genetics

For any parent, learning after delivery that their baby may have a serious chromosomal condition can be heartbreaking and scary. Unfortunately, some conditions are very difficult to detect during pregnancy without invasive diagnostic testing, which may not be indicated for a young, healthy pregnant person with a typically progressing pregnancy.  Such is the case with the 22q11.2 microdeletion syndrome, a relatively common and potentially serious chromosomal abnormality. 22q, as it is colloquia

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Vascular Ultrasound: What Is It and How Does It Work?

Vascular Physician

Vascular Ultrasound: What Is It and How Does It Work? When it comes to monitoring the condition of your veins and arteries, a vascular ultrasound can help. Whether you are showing signs of a vascular concern, have been diagnosed with a disease, or are striving to prevent a vascular illness from occurring in the future, a vascular ultrasound can give your healthcare provider a clear image of how well blood is flowing to the organs and tissues throughout your body.

IT 52
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Demystifying Autism: Understanding the Spectrum

Family Physicians of Greeley

Welcome to our journey to demystify autism spectrum disorder (ASD). Whether you’re a parent, caregiver, educator, or simply curious about autism, this post aims to provide a comprehensive overview of what autism is and what it means for individuals and their families. Defining Autism Spectrum Disorder (ASD): Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by differences in social communication and interaction, as well as restricted interests and repetitive b

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5 Early Signs of Parkinson’s Disease

Logansport Memorial Hospital

Did you know that every 6 minutes, someone in the United States is diagnosed with Parkinson’s Disease? Before 2022, it was estimated that 60,000 people in the United States were diagnosed with Parkinson’s Disease each year. Of those 60,000 people diagnosed, 10 – 20% were under 50 years old. Parkinson’s Disease does not only effect older populations, and it’s important to know the signs so that you can catch it early.

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Episode 328 – Clinical Unknown – Alec & Austin discuss Lauren’s case

The Clinical Problem Solvers

[link] Débora and Noah bring back the Clinical Unknown Series! To kick off the first episode, we host Alec and Austin, who discuss a case presented by Laure. Embark on this diagnostic journey with us!

Clinic 52
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FDA’s Draft Guidance on the Q-Submission Program – A Step in the Wrong Direction

FDA Law Blog

By Lisa M. Baumhardt, Senior Medical Device Regulation Expert — FDA recently issued a draft guidance on Requests for Feedback and Meetings for Medical Device Submissions: The Q-Submission Program , which included some changes over the existing guidance which could have a negative impact on future pre-submissions. The draft guidance attempted to clarify when a Sponsor’s question may be more appropriate for more informal communication.

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Dense Breasts, Cancer Prevention and Early Detection

Myriad Genetics

Boobs. The Girls. Tatas. Breasts have a lot of names and yet most people have very little understanding of them and how they work, and likely even less understanding of breast cancer. Cancer Prevention and Early Detection Month, observed in April, is a perfect opportunity to fix that, including sharing critical information about dense breasts. Dense breast tissue is normal. 1 People can have it for a number of reasons, including genetics, age (breast tissue tends to get less dense over time, and

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Tips for Preventing Blood Clots During Travel

Vascular Physician

Tips for Preventing Blood Clots During Travel When you travel for long periods of time (four hours or more), you are at an increased risk to develop a venous blood clot in one of your legs due to a lack of mobility. The good news is that you don't have to avoid traveling to protect your cardiovascular health. Check out these simple steps that can help prevent blood clots while you travel.

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Tools you should use: Pediatric NIH Stroke Scale

PEMBlog

Pediatric strokes are rare and challenging to diagnose. There is a validated Pediatric Stroke Scale from the NIH that can be used in conjunction with a stroke protocol that involves Neurology, Radiology, and a local/regional Stroke Team. Review the tool at MD Calc, the direct link is – [link] – MD Calc Pediatric NIH Stroke Scale Important notes The overall true predictive value of the Pediatric NIH stroke scale continues to be studied.

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Angling a Babel Fish: the Evolving Role of AI Language Models in Medical Interpretation - Clinical Correlations

Clinical Correlations

By Eric Hu Peer Reviewed “May I have the patient’s first name, last name, and medical record number?” The fellow, shooting a piercing glance at the interpreter through the wall-mounted phone, broadcasted her annoyance at the.

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Episode 329 – Spaced Learning Series – Mystery Case

The Clinical Problem Solvers

[link] The Spaced Learning Series discuss a fascinating new case of a patient found down. Featuring: Anna Fretz Priyanka Athavale Kirtan Patolia Schemas: Hyperkalemia Lactic Acidosis Hypothermia Hyperammonemia Download CPSolvers App here RLRCPSOLVERS Click here to view the weekly episode recap email!

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FDA’s Revised Draft Guidance on Biological Product Promotion Provides Additional Recommendations/Clarifications

FDA Law Blog

By Sarah Wicks & Dara Katcher Levy — On April 24, 2024, the FDA issued a revised draft guidance, Promotional Labeling and Advertising Considerations for Prescription Biological Reference Products, Biosimilar Products, and Interchangeable Biosimilar Products – Questions and Answers , (the “Revised Draft Guidance”) which replaces the Agency’s initial draft guidance issued in February 2020 (the “Initial Draft Guidance”).

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Surrogate Decision Making: Bernie Lo and Laurie Dornbrand

GeriPal

Summary Transcript Summary In 1983, a 25 year old Nancy Cruzan was thrown from her car while driving home in Missouri, landing in a water filled ditch. She was resuscitated by EMS, but did not regain higher brain function, and was eventually diagnosed as being in a persistent vegetative state. In 1988, Cruzan’s parents requested that her feeding tube be removed, arguing that she would not want to continue in this state.

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Provider Perspective: How a friend’s diagnosis inspired one doctor to do more cancer risk testing 

Myriad Genetics

Dr. Burton Brodsky had been an OB-GYN for years when his neighbor – and one of his wife’s closest friends – came to him with a question. She was wondering if she should be tested for this “BRCA gene.” Dr. Brodsky inquired about her family, and she told him that both sides of her family had an extensive history of ovarian cancer and breast cancer. “I told her she absolutely needed to be tested,” said Dr.

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Happy 17th Anniversary to my Amazing Wife!

PEMBlog

The only annual “non-medical” post to PEMBlog is here. My annual anniversary video that I produce for my wife. Ok, so it has become clear by now that I’m having difficulty making it to Hallmark to buy an appropriate anniversary card. Are there any stores still open in the Greater Cincinnati area? I’m not sure anymore. I need to own up to my failures.

IT 52
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Challenges with Polypharmacy in the Geriatric Population - Clinical Correlations

Clinical Correlations

By Olivia Descorbeth Peer Reviewed As individuals advance in age, they tend to accumulate medical conditions that require a bevy of pharmaceutical treatments to manage. As a result, polypharmacy, generally defined as the use of five.

Clinic 52
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Episode 327: WDx #28: “Anonymous was a Woman”

The Clinical Problem Solvers

[link] In honor of Women’s History month in the United States, Sharmin, Kaylin, and Jane discuss the Matilda Effect, the current state of gender inequality, and reflect on some of the many incredible women scientists that came before us and helped pave the way for a better future. For more on the topics discussed, check out: Women Scientists Were Written Out of History.

Medical 52
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OMB Completes its Review of the Final LDT Rule—A Final Rule Coming Anytime Now

FDA Law Blog

By Allyson B. Mullen & Jeffrey N. Gibbs — We’ve been hearing for quite some time that a Final LDT Rule would likely be coming this spring, before May 1. This timing has been attributed to FDA’s desire to avoid having the rule being overturned by Congress under the Congressional Review Act. Of course, if a new administration takes over next year, the rule’s future would be questionable, even without congressional action.

IT 59
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What Is the Importance of Preventative Medical Care?

Hitchcock Family Medicine

Staying healthy requires more than just watching your diet and exercising every week. There are also important types of preventive medical care that need to be done as well with your family care physician. According to Forbes, adults in the U.S. who have a primary care provider have 19% lower odds of premature death than those who only see specialists for their care when needed.

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The Importance of Cancer Prevention and Early Detection

Myriad Genetics

Cancer. The very word is often whispered, as it strikes fear and uncertainty into people as they go about their everyday lives. Among the various types of cancer, breast cancer remains one of the most prevalent. “Each year in the United States, about 240,000 cases of breast cancer are diagnosed in women and about 2,100 in men,” according to the Centers for Disease Control and Prevention (CDC) website.

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What is primary care? Part 2

Noreta Family Medicine

What is primary care? Part 2 Here are some frequently asked questions I get as a Primary Care Provider. What is the meaning of Family Medicine? As the name suggests, a family physician can take care of your entire family – from the day of your birth (even before!) to your last day on Earth, as I like to say! During our post-medical school residency years, we are trained by many different types of doctors including pediatricians, OB/GYNs, surgeons, psychiatrists, neurologists, ENTs and more.

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Buprenorphine After the X-Waiver - Clinical Correlations

Clinical Correlations

By Sarah M. Jackson Peer Reviewed During the COVID-19 pandemic, opioid overdose deaths increased from 50,000 in 2019 to 80,000 in 2021, largely driven by synthetic opioids such as fentanyl.1 Despite the escalating use of synthetic.

Clinic 52
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Episode 330 – Spaced Learning Series – Fever and Rash (and a new chapter)

The Clinical Problem Solvers

[link] Our new members of the Spaced Learning Series team, Jasdeep and Mukund, join Valeria to discuss a case of progressive rash. Featuring: Valeria Roldan Jasdeep Bajwa Mukund Raguram Schemas Fever and Rash Download CPSolvers App here RLRCPSOLVERS Click here to view the weekly episode recap email!

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Senators to DEA: Consider Treaty Obligations In Marijuana Rescheduling

FDA Law Blog

By Larry K. Houck — Administrator Anne Milgram has been on the receiving end of high-level support for and against rescheduling marijuana since the Food and Drug Administration (“FDA”) and Health and Human Services (“HHS”) recommended the Drug Enforcement Administration (“DEA”) reschedule from schedule I to schedule III last August. We blogged in February about the October 2023 letter from former DEA Administrators, Ms.

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The Promise and Pitfalls of AI in Medicine: Guest Bob Wachter

GeriPal

Summary Transcript Summary Eric asks the question that is on many of our minds – is the future of AI more Skynet from Terminator, in which AI takes over the world and drives humanity to the brink of extinction, or Wall-E, in which a benevolent and empathetic AI restores our humanity? Our guest today is Bob Wachter, Chair of Medicine at UCSF and author of the Digital Doctor: Hope, Hype, and Harm at the Dawn of Medicine’s Computer Age.

IT 139
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8 Reasons Why Family Physicians are the Actual Stars of Medicine

Family Medicine Initiative

Family medicine is neither the most prestigious nor the highest paid medical profession. Is that appropriate, or should it be the opposite? Should GPs actually be treated as the stars of medicine? As a general practitioner and primary care researcher, it was always fascinating for me to delve into the scientific literature to investigate this issue.

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How to Find More Quality Blog Posts on Respiratory Infections in Children: Findings from a SOAR Review

PEMBlog

Be sure to check out our previous posts on: BRONCHIOLITIS , EPIGLOTTITIS , PNEUMONIA , and CROUP The Problem: Free open access medical education (aka FOAM) is great in that it allows for asynchronous, focused learning. But there are some challenges when it comes to the utilization of FOAM: – Decentralization of FOAM resources – Concerns about the quality of information being presented The Solution: The Systematic Online Academic Resource, or SOAR, review was created in an effort to address some

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“Heigh-ho” Taiho! The PTO Says LYTGOBI Patent is Ineligible for PTE Because of Untimely Application. And a Corrected NDA Approval Letter is No Saving Grace

FDA Law Blog

By Kurt R. Karst — If you’ve been following this blog since the early days, then you know we fervently followed the more-than-decade-long soap opera that was The Medicines Company’s efforts to obtain a Patent Term Extension (“PTE”) from the U.S. Patent and Trademark Office (“PTO”) for U.S. Patent No. 5,196,404 covering ANGIOMAX (bivalirudin) after the company’s patent counsel untimely filed for a PTE 62 days after the ANGIOMAX NDA 020873 approval at 5:18 PM on Friday, December 15, 2000 (see our

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Clear that Cabinet Tour ‘24

FDA Law Blog

By Larry K. Houck — Medicine cabinet, stuffed to the gills Capsules, liquid, patches, and pills Expired oxy, hydro, benzos, and more All kind of old meds flowing out the door We will, we will, clear you We will, we will, clear you Back by popular demand, coming to a collection site in your town for one day only, is a return of the ever popular Drug Enforcement Administration’s (“DEA’s”) National Prescription Drug Take Back Day.

Medical 59
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The Fourth Circuit Upholds CMS’ Definition of “Line-Extension Drug” and “New Formulation”

FDA Law Blog

By Sophia R. Gaulkin — On April 10, the Fourth Circuit unanimously affirmed a summary judgment ruling for the Centers for Medicare & Medicaid Services (CMS) regarding the agency’s definitions of “line-extension drug” and “new formulation” for purposes of determining rebates that drug manufacturers may owe the Medicaid Drug Rebate Program (MDRP).