Sun.Jul 20, 2025

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Clinical Outcomes of MILD in Lumbar Stenosis

Physician's Weekly

Minimally invasive lumbar decompression showed promising, high-quality evidence for improving pain and function in individuals with LSS. A study published in July 2025 issue of Journal of Pain Research examined the limited evidence on short- and long-term outcomes of minimally invasive lumbar decompression (MILD) in managing pain and disability due to lumbar spinal stenosis (LSS).

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Rising maternal mortality is fuelling distrust in the medical establishment in Georgia

NPR Health

Maternal mortality rates are rising, especially for Black women. In one community in Georgia, some women say they are losing trust in doctors and hospitals.

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Navigating Mental Health Referrals Through General Practice

Physician's Weekly

Poor GP communication and fragmented referrals worsened mental distress, highlighting the urgent need for patient-centered mental health navigation. A study published in July 2025 issue of Journal of Primary Care & Community Health stated a limited insight into how individuals in Norway experience accessing specialized mental health services through general practice, despite rising mental health concerns.

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How Exercise Helps Manage Prediabetes (Even Just Walking)

Vida Family Medicine

If you’ve been told that managing pre-diabetes means signing up for a gym membership or committing to a strict workout regimen, I want to offer you a more compassionate—and realistic—alternative. I’m Dr. Rebecca Berens, family physician and founder of Vida Family Medicine. In this post, I’ll explain why small, sustainable changes in your daily movement can make a meaningful impact on your blood sugar—and how to do it without flipping your entire life upside down.

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How to Start Virtual Care the Right Way: A Proven Roadmap for 2025 and Beyond

Speaker: Dr. Christine Gall, DrPH, MS, BSN, RN

The promise of virtual care is no longer theoretical and is now a critical solution to many of healthcare’s most urgent challenges. Yet many healthcare leaders remain unsure how to build a business case for investment and launching the right program at the right time can be the difference between value and failure. For organizations seeking a financially sound, clinically effective entry point, Virtual Patient Observation (VPO) offers a compelling case to lead with.

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Remote Blood Collection Validates Neurofilament Light Stability

Physician's Weekly

A finger-prick blood test reliably measures neurofilament light, enabling remote monitoring that could revolutionize neurological disease management and research. A study published in July 2025 issue of Journal of Neurology highlighted the potential of blood -based neuropathology biomarkers for therapy and monitoring, while emphasizing the need for specialist services and the benefits of remote sampling to ease clinical visit burdens.

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The cost of ending shadowing in medical education

KevinMD

A faculty-wide email recently announced that shadowing in our emergency department would no longer be recognized as a valid educational activity. I wrote back asking why. The reply was brief, dismissive, and telling: “It doesn’t pay the rent.” That line has stuck with me—not just because it was flippant, but because it revealed something deeper Read more… The cost of ending shadowing in medical education originally appeared in KevinMD.com.

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The hidden cost of professionalism in medical training

KevinMD

I sat in my pink childhood bed, my name still written in cursive above it from when I redesigned the room at seven years old, staring at the letter that shattered my dream. I had been dismissed from medical school for “professionalism” concerns. I didn’t know what came next. No roadmap. No support. Just the Read more… The hidden cost of professionalism in medical training originally appeared in KevinMD.com.

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Supporting Self-Management in Chronic Care Practice

Physician's Weekly

GPs underlined the need for improved, structured support to sustain SM in chronic care beyond current program standards. A study published in July 2025 issue of BMC Primary Care highlighted the critical role of self-management (SM) in chronic disease care and managed the limited information available on its integration within German disease management programs (DMP).

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Turning 40 and Feeling Off? How to Recognize Perimenopause Before the Hot Flashes Hit

Vida Family Medicine

Perimenopause isn’t a switch that flips overnight—it’s a gradual, whole-body transition that can unfold over the course of a decade. Many women begin experiencing symptoms in their late 30s or early 40s, often long before the classic hot flashes or skipped periods. These early signs are frequently mistaken for stress, aging, or other medical issues, leaving women feeling confused or dismissed.

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Clinical Effects of Pramipexole in Nonresponsive Depression

Physician's Weekly

Pramipexole added to antidepressants improved depressive symptoms at 12 weeks, offering a promising option for treatment-resistant cases despite some side effects. A study published in June 2025 issue of Lancet Psychiatry reported that approximately 30% of individuals with depression do not respond adequately to initial antidepressant therapy, and pramipexole may offer a potential augmentation strategy in treatment-resistant cases, though evidence on its efficacy and tolerability remains limit

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"The Trouble is.

Mere Mortal MD

I came across this quote the other day while reading LoveStory , a substack from Laura McKowen, an inspiring writer I have followed ever since I got sober with the help of her community, The Luckiest Club. In her newsletter she spoke of how she kept putting off getting sober, thinking she could do so anytime in the future once she really committed to the decision.

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Development and validation of a nomogram for predicting postoperative recurrent lumbar disc herniation after unilateral biportal endoscopic discectomy.

Physician's Weekly

No study has investigated the incidence or risk factors of recurrent lumbar disc herniation (rLDH) after unilateral biportal endoscopic discectomy (UBED) in patients with lumbar disc herniation. Therefore, we aimed to construct and verify a nomogram that can predict the risk of recurrence after UBED for lumbar disc herniation and therefore help clinicians understand the recurrence rate of lumbar disc herniation before surgery and formulate corresponding interventions to improve the prognosis of

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To ward off pesky mosquitoes this summer, use the three D's — drain, dress, defend

NPR Health

We look at the best ways to prevent mosquito bites and how small steps can make a big difference during mosquito season.

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Research on the spectrum of complications in robotic surgery for obese urologic patients: a 6-year retrospective study.

Physician's Weekly

The prevalence of obesity has reached epidemic proportions globally, with obese patients facing significantly higher perioperative risks due to anatomical and physiological challenges. While robot-assisted surgery (RAS) offers potential advantages through 3D high-definition imaging and tremor filtering capabilities, comprehensive safety data for obese patients remains limited.

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Why Trump has championed the vaping industry

NPR Health

NPR's Adrian Ma speaks to Nicholas Florko from The Atlantic about President Trump's support for the vaping industry, which contradicts his stance during his first administration.

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Accuracy of PEF in Detecting Bronchodilator Response in Asthma

Physician's Weekly

PEF failed to consistently reflect FEV 1 improvements after bronchodilation, indicating that handheld spirometry may better support asthma diagnosis and home monitoring. A study published in July 2025 issue of Pulmonary Medicine reported that asthma diagnosis may be confirmed by demonstrating a significant bronchodilator response (BDR) using peak expiratory flow (PEF) measurements at home or forced expiratory volume in 1 second (FEV 1 ) assessed through spirometry in clinical settings.

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Why hospital jobs are failing physicians: burnout, pay, and lost autonomy

KevinMD

Hospital employment was once billed as the solution to the headaches of private practice — a way to gain stability, reduce administrative burden, and focus on patient care. But for many physicians, that promise has come undone. According to the Physicians Foundation’s 2024 report, 60 percent of physicians report frequent feelings of burnout — the Read more… Why hospital jobs are failing physicians: burnout, pay, and lost autonomy originally appeared in KevinMD.com.

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Automated Skin Prick Test Matched Accuracy for Allergy Detection

Physician's Weekly

Digital and manual SPAT readings reliably identified allergic sensitization, supporting its clinical use alongside standard testing. Researchers conducted a retrospective study published in July 2025 issue of European Journal of Allergy and Clinical Immunology to clinically validate the adjusted cut-off for the Skin Prick Automated Test (SPAT) in individuals with confirmed birch or house dust mite (HDM) allergy.

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Sometimes, Timing is Everything

FDA Law

By Charles D. Snow — A recent appellate court decision vacating a Federal Trade Commission (“FTC”) rule on procedural grounds may spell the end of the effort to implement the “Negative Option Rule.” For any blog reader who has ever missed that cancellation deadline and found themselves saddled with another month (or year) of a streaming service or gym membership, this decision may be of personal interest, but, for regulated industry, it highlights how a procedural win can sometimes be a full vic

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Real-world outcomes of selective laser trabeculoplasty and medical treatment in primary open-angle glaucoma and ocular hypertension.

Physician's Weekly

Report effectiveness of selective laser trabeculoplasty (SLT) and topical medical therapy for treatment initiation and escalation. Multicentre, retrospective cohort study covering an observation period of 10 years. Patients with ocular hypertension or primary open-angle glaucoma initiating intraocular pressure (IOP)-lowering therapy, or escalating from a single topical agent.

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Prevalence and risk factors of anxiety and depression among non-communicable diseases clinic attendees in rural Rwanda: a cross-sectional study.

Physician's Weekly

This study aimed to estimate the prevalence of depression and anxiety and associated risk factors among non-communicable diseases (NCD) clinic attendees in rural Rwanda. Cross-sectional. 44 health centres in three rural districts in Rwanda. Adults aged 18 years and older with a clinical diagnosis of diabetes, hypertension and/or asthma, who were attending a follow-up appointment during the study period (n=595).

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Predictors of Improvement in Subjective Executive Functioning Following an Internet-Delivered Cognitive Enhancement Intervention for Adults in Remission From Depression.

Physician's Weekly

Residual cognitive deficits are commonly reported by individuals in remission from depression, often affecting daily life functioning and mental health. To provide tailored and personalized cognitive enhancement interventions for this population, there is a need for a better understanding of the characteristics of those who benefit from such interventions.

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Biologic Therapy Benefits in Polymyalgia Rheumatica

Physician's Weekly

Sarilumab enhanced QoL and symptom relief in individuals with polymyalgia rheumatica who struggled with standard glucocorticoid therapy. Researchers conducted a retrospective study published in July 2025 issue of Lancet Rheumatology to assess the impact of sarilumab on patient-reported outcomes in adults with polymyalgia rheumatica who had an inadequate response to or intolerance of corticosteroid tapering.

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Thyroidectomy Outcomes Unaffected by Obesity

Physician's Weekly

Obesity did not increase surgical risks in thyroidectomy, despite longer operative times. Researchers conducted a retrospective study published in July 2025 issue of BMC Surgery to examine how body mass index (BMI) influenced the rate of surgical complications among individuals who underwent thyroidectomy. They assessed 84 individuals who underwent open total thyroidectomy.

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Economic Factors Influence Robotic RC Implementation

Physician's Weekly

Wealthier markets and hospital capacity were key drivers of robotic radical cystectomy adoption, independent of local competition. Researchers conducted a retrospective study published in July 2025 issue of Urology Practice to examine how market-level characteristics influenced hospitals’ likelihood of adopting robotic radical cystectomy (RC) prior to the availability of randomized data confirming its oncologic noninferiority.

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Group-Based Peer Support Improves Personal Recovery Scores

Physician's Weekly

The PEER intervention led to meaningful improvements in recovery, highlighting its potential as a scalable approach to mental health services. A study published in July 2025 issue of BMC Psychiatry reported that community-based peer support served as a valuable adjunct to regional mental health services by facilitating personal recovery among individuals.

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Mortality Scores in Bacteraemia Show Varying Predictive Value

Physician's Weekly

Bacteraemia-specific scores outperformed general tools in predicting 30-day mortality, underscoring their value in guiding clinical decisions. Researchers conducted a retrospective study published in July 2025 issue of Infectious Diseases to evaluate the validity of predictive mortality scores for bacteraemia in external cohorts. They assessed the performance of several scoring systems—Charlson, age-adjusted Charlson, updated Charlson, SOFA, Pitt, INCREMENT-ESBL, and BSIMRS-in predicting 3

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Spectrophotometric and Pulse Oximetry Assessment of Neonatal Skin Tone

Physician's Weekly

Skin tone varied but overlapped among neonates, supporting pigment-based over race-based measures. Researchers conducted a retrospective study published in July 2025 issue of Journal of Pediatrics to analyze differences and similarities in skin pigmentation among neonates born to mothers from various racial groups, focusing on how pulse oximetry readings may be affected.

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Low Rehospitalization Risk After Initial RSV Admission

Physician's Weekly

Rehospitalization for RSV within the same season was rare, suggesting limited need for routine additional monoclonal antibody dosing. Researchers conducted a retrospective study published in July 2025 issue of BMC Pediatrics to examine the risk of Respiratory Syncytial Virus (RSV) rehospitalization, particularly same-season cases, among children with a history of severe initial RSV infection.

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Elevated GDF-15 Indicates Fibrosis

Physician's Weekly

GDF-15 emerged as a promising non-invasive indicator for detecting liver fibrosis in individuals with sickle cell disease. Researchers conducted a retrospective study published in July 2025 issue of International Journal of Hematology to examine the association between growth differentiation factor-15 (GDF-15) levels and liver fibrosis in individuals with sickle cell disease (SCD) and to evaluate its potential as a non-invasive biomarker.

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Efficacy of Low-frequency Acupuncture Therapy based on Midnight-Noon Acupuncture for the Central Neurogenic Bladder: A Randomized Controlled Trial.

Physician's Weekly

This study aims to investigate the therapeutic efficacy and complications of low-frequency acupuncture therapy based on Midnight-Noon Acupuncture in the central neurogenic bladder (CNB). This study is a prospective, randomized controlled trial. Sixty patients diagnosed with CNB without prior treatment were randomly divided into two groups: the control group (n=30) was treated with basic rehabilitation training, and the treatment group (n=30) was treated with basic rehabilitation training plus lo

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Rifamycin SV-MMX Reduces Pain and Diarrhea in IBS-D

Physician's Weekly

Twice-daily rifamycin SV-MMX offers rapid and longer-term relief in diarrhea-predominant IBS compared to placebo and higher dosing. Researchers conducted a retrospective study published in July 2025 issue of American Journal of Gastroenterology to evaluate the effectiveness of rifamycin SV-MMX in managing symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D).

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Epidemiologic Decline in Chronic Hepatitis C Infection

Physician's Weekly

Repeat testing data revealed a marked decline in hepatitis C incidence, underscoring progress toward elimination of targets. A study published in July 2025 issue of Lancet Gastroenterology and Hepatology highlighted Georgia’s progress toward hepatitis C elimination and emphasized the need to monitor new hepatitis C virus (HCV) cases as the country approaches low-incidence targets set by the WHO.

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Imaging Reveals Pancreatic Decline in Type 1 Diabetes

Physician's Weekly

Pancreatic volume loss tracked by CT imaging may offer a valuable non-invasive marker for type 1 diabetes progression. A study published in July 2025 issue of Endocrine reported that, beyond beta-cell loss, individuals with type 1 diabetes (T1D) also exhibit exocrine pancreatic abnormalities detectable through imaging. Researchers evaluated exocrine pancreatic changes across different stages of T1D using CT scans, including assessments before clinical diagnosis.

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Synthetic oleanolic acid derivative, RTA-408, overcome in TMZ-resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest.

Physician's Weekly

Glioblastoma is the most malignant primary brain tumor. It is characterized by high cellular heterogeneity, which contributes to its high chemoresistance and recurrence rate. To investigate the anticancer effect of RTA-408 on TMZ-resistant glioblastoma, we developed 2 TMZ-resistant cell lines, GBM841R and U-87MGR. Our findings revealed that RTA-408 (Omaveloxolone) effectively inhibited growth, induced cytotoxicity, and reduced colony formation in TMZ-resistant glioblastoma cells.

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Epitope Targeting Enables Broad S.aureus Coverage

Physician's Weekly

AZD7745 targets a conserved ClfA epitope, offering broad neutralization across diverse Staphylococcus aureus strains. Researchers conducted a retrospective study published in July 2025 issue of Journal of Infectious Diseases to determine the epitope targeted by AZD7745 and assess its conservation and neutralizing activity across a global collection of Staphylococcus aureus bacteremia isolates.

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