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SGLT-2 inhibitor, cardiovascular risk and outcome in patients with comorbidity of hypertension and diabetes [Cardiovascular disease]

Annals of Family Medicine

Context Two thirds of diabetes patients complicated with hypertension, and comorbidity increase 4-fold risk of atherosclerotic cardiovascular disease (ASCVD). Population Studied individuals with comorbidity of hypertension and type 2 diabetes. Outcome Measures Changes of China-PAR score and cardiovascular hospitalization events.

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DASH Diet for Diabetes With Low Sodium Reduces BP in Those With Diabetes

Physician's Weekly

WEDNESDAY, June 18, 2025 (HealthDay News) — The Dietary Approaches to Stop Hypertension for Diabetes (DASH4D) diet with lower sodium is tied to clinically meaningful blood pressure reduction in people with diabetes, according to a study published online June 9 in JAMA Internal Medicine. Pilla, M.D., Pilla, M.D.,

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Key Facts GPs Should Know About GLP-1 Analogs

Family Medicine Initiative

Cardiovascular Events The SELECT trial 1 randomized 17,604 patients with preexisting CVD and overweight/obesity. Relative risk for cardiovascular events was reduced by 19% (RRR), while the absolute risk was reduced by 1.5% 5 In March 2024, Novo Nordisk announced that 24% less CKD-related events occurred in the intervention group.

Diabetes 130
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ADA: Orforglipron Reduces Glycated Hemoglobin in Early Type 2 Diabetes

Physician's Weekly

from the Velocity Clinical Research Center at Medical City Dallas, and colleagues conducted a phase 3 trial involving participants with type 2 diabetes treated only with diet and exercise, an HbA1c level of ≥7.0 Mild-to-moderate gastrointestinal events were the most common adverse events with orforglipron. Julio Rosenstock, M.D.,

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FDA Approves Polypill Widaplik for Hypertension

Physician's Weekly

The most common adverse event reported in patients treated with Widaplik was symptomatic low blood pressure. Widaplik is not to be coadministered with aliskiren in patients with diabetes, and a boxed warning indicates discontinuation of Widaplik during pregnancy.

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Transfibular Total Ankle Arthroplasty Seems Effective for End-Stage Arthritis

Physician's Weekly

from MedStar Union Memorial Hospital in Baltimore, and colleagues retrospectively identified and evaluated 130 ankles from 122 patients with a mean follow-up of 5.9 percent) had adverse events, with medial gutter debridement (22 ankles; 16.9 Jonathan Day, M.D., Three cases of cysts occurred (2.3 At a mean of 26.7 months, 47 ankles (36.2

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Why Identifying and Managing Giant Cell Arteritis as an Emergency Is Crucial

Physician's Weekly

If there’s visual symptoms, patients are often hospitalized for high dose intravenous symptoms. Important to note that GCA patients are older, many have comorbidities such as diabetes, failed cardiovascular disease or psychiatric risks. But treatment first, securing the diagnosis is secondary and often delayed.