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Clinical Reasoning Corner: Likelihood Ratios

The Clinical Problem Solvers

Clinical Reasoning Corner: Likelihood Ratios By Jack Penner Welcome back, Clinical Problem Solvers! Thank you for reading the latest post in our “Clinical Reasoning Corner”, where we discuss key clinical reasoning principles that shape how we think through cases. To do that, we need to rely on LRs.

Clinic 52
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Ocular Toxicities of Targeted Cancer Therapies

Physician's Weekly

The following is a summary of “Clinical and imaging strategies for the assessment of the ocular side effects of systemic targeted anti-cancer therapies,” published in the April 2025 issue of the European Journal of Cancer by Michaels et al.

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Key Facts GPs Should Know About GLP-1 Analogs

Family Medicine Initiative

I therefore reviewed the main research studies and guidelines and tried to summarize them briefly and clearly in this article. Yes, one year after stopping the medication, patients regain ½ – ⅔ of their previous weight loss: What are other clinical benefits? How effective are GLP-1 analogs for weight loss? over 40 months (ARR).

Diabetes 130
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A deeper dive into GPA – Jack Penner

The Clinical Problem Solvers

Welcome back, Clinical Problem Solvers! Clinical Manifestations We often think of GPA as a pulmonary-renal syndrome, but, while many patients develop renal complications, a much smaller percentage present with them. Some of our favorite articles on the topic are listed below.

Illness 52
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Q&A: Physicians Weigh Improvements in MASLD Treatment Against Gaps in Assessment Strategies

Physician's Weekly

“[Metabolic dysfunction-associated steatotic liver disease (MASLD)] closely relates to obesity, insulin resistance and type 2 diabetes, with which it shares many pathogenetic features” researchers wrote in Metabolism. PW: Why was it important to do this study? PW: How may this summary affect patient care?

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Overtreatment of prostate cancer in the active surveillance era

Common Sense Family Doctor

Concerns about overdiagnosis of clinically insignificant prostate cancer through prostate specific antigen (PSA) screening motivated the 2018 American Academy of Family Physicians’ (AAFP) recommendation against routine screening for prostate cancer. Watchful waiting refers to clinical observation only. A recent analysis of the U.S.

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Updates in ID and Nephrology: Lona Mody, Rasheeda Hall, Devika Nair, Sonali Advani

GeriPal

Sonali Advani and Lona Mody talk about their recent JAGS article highlighting three recent articles that every clinician caring for older adults should be aware of in the treatment of infectious diseases (hint: I’ve never finished a course of antibiotics, and maybe your patients don’t need that full course either). This is Eric Widera.