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Clinical Reasoning Corner: Likelihood Ratios

The Clinical Problem Solvers

Clinical Reasoning Corner: Likelihood Ratios By Jack Penner Welcome back, Clinical Problem Solvers! Thank you for reading the latest post in our “Clinical Reasoning Corner”, where we discuss key clinical reasoning principles that shape how we think through cases. How Can I Use Likelihood Ratios in My Own Practice?

Clinic 52
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Ocular Toxicities of Targeted Cancer Therapies

Physician's Weekly

The following is a summary of “Clinical and imaging strategies for the assessment of the ocular side effects of systemic targeted anti-cancer therapies,” published in the April 2025 issue of the European Journal of Cancer by Michaels et al.

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Foreskin care: Hygiene, importance of counselling, and management of common complications

Canadian Family Physician

Sources of information This review is based on findings from a MEDLINE database search of the literature on care of the penile foreskin, foreskin complications, and their management. Articles were reviewed for relevance and quality of evidence was provided with the level of evidence in parentheses throughout the review.

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Key Facts GPs Should Know About GLP-1 Analogs

Family Medicine Initiative

I therefore reviewed the main research studies and guidelines and tried to summarize them briefly and clearly in this article. Yes, one year after stopping the medication, patients regain ½ – ⅔ of their previous weight loss: What are other clinical benefits? How effective are GLP-1 analogs for weight loss? over 40 months (ARR).

Diabetes 130
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A deeper dive into GPA – Jack Penner

The Clinical Problem Solvers

Welcome back, Clinical Problem Solvers! Clinical Manifestations We often think of GPA as a pulmonary-renal syndrome, but, while many patients develop renal complications, a much smaller percentage present with them. Some of our favorite articles on the topic are listed below.

Illness 52
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Overtreatment of prostate cancer in the active surveillance era

Common Sense Family Doctor

Concerns about overdiagnosis of clinically insignificant prostate cancer through prostate specific antigen (PSA) screening motivated the 2018 American Academy of Family Physicians’ (AAFP) recommendation against routine screening for prostate cancer. Watchful waiting refers to clinical observation only. A recent analysis of the U.S.

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Helping Patients Preserve Muscle Mass During Weight Loss

Physician's Weekly

Liver cT1, a biomarker of liver inflammation and fibrosis, decreased slightly (by 1%, or 10 ms), but this change was not clinically significant. However, the concurrent loss of muscle mass—even in the context of favorable fat loss—can cause health complications, particularly in older adults.